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Towards precision medicine in severe asthma: Treatment algorithms based onTowards precision medicine in severe asthma: Treatment algorithms based ontreatable traits

Andriana I. Papaioannou, Zuzana Diamant, Petros Bakakos, Stelios Loukides

Abstract

Asthma is a common disease, and although its clinical manifestations may be similaramong patients, recent research discoveries have shown that it consists of severaldistinct clinical clusters or phenotypes, each with different underlying molecularpathways yielding different treatment responses. Based on these observations, analternative approach - known as ‘precision medicine’ - has been proposed for themanagement of patients with severe asthma. Precision medicine advocatesidentification of treatable traits, linking them to therapeutic approaches targetinggenetic, immunological, environmental, and/or lifestyle factors in individual patients.The main “goal” of this personalized approach is to enable choosing a treatmentwhich will be more likely to produce a beneficial response in the individual patientrather than a ‘one size fits all’ approach. The aim of the present review is to discussdifferent ways of phenotyping asthma and to provide a rationale for treatmentalgorithms based on principles of precision medicine.

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Valores IMPERA

01

Liderazgo personal y colectivo en el ámbito de la Medicina de Precisión

02

Calidad en la búsqueda de excelencia de los nuevos desarrollos

03

Independencia de las instituciones oficiales, sociedades científicas y organizaciones no gubernamentales o empresariales para garantizar trasparencia y objetividad.

04

Promoción de soluciones costo-efectivas para los problemas de salud en el campo de la medicina respiratoria y la alergología

05

Compromiso con la circulación democrática de las ideas y conceptos

06

Solidaridad en la transferencia de los nuevos conocimientos científicos y tecnológicos para mejorar la vida de las personas, sus familias y  comunidades.

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